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On the other hand, this biomolecule is also able to alleviate angiogenesis, as both the reduced expression of vascular endothelial growth factor-A (VEGF-A) genes [50] as well as inhibition of the nuclear factor kappa B (NF-B) pathway participating in neovascularization [48] were found in two studies on cellular models

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Despite these promising findings, several challenges remain

Mild side effects such as nausea, digestive changes, or fatigue may occur, but they typically improve as the body adjusts

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Tumor-derived retinoic acid regulates intratumoral monocyte differentiation to promote immune suppression